Nature Genetics, Published online: 20 May 2019; doi:10.1038/s41588-019-0421-zRelease of paused Pol II at specific intronic loci or chromatin domains favors the formation of abnormal DNA recombination, leading to cancer-associated chromosomal translocations. […]

Nature Genetics, Published online: 20 May 2019; doi:10.1038/s41588-019-0414-yThe authors present a new genomic prediction method for maize germplasm evaluation under genotype × environment interaction, in which genotype × environment interaction of grain yield components is modeled as genotypic sensitivity to environmental drivers. […]

Nature Genetics, Published online: 20 May 2019; doi:10.1038/s41588-019-0408-9CRISPR screens identify JNK–JUN family genes as repressors of definitive endoderm differentiation in human pluripotent stem cells. JUN co-occupies stem cell enhancers with OCT4, NANOG, SMAD2 and SMAD3 and inhibits the exit from pluripotency. […]

Nature Genetics, Published online: 20 May 2019; doi:10.1038/s41588-019-0438-3Author Correction: New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries […]

Nature Genetics, Published online: 17 May 2019; doi:10.1038/s41588-019-0437-4Publisher Correction: Landscape of B cell immunity and related immune evasion in human cancers […]

Ludwig-Maximilians-Universitaet (LMU) in Munich researchers have used CRISPR technology to probe the mechanisms that guide the developmental trajectories of stem cells in the brain. The results show that crucial cellular switches are doubly protected against unintended activation. […]

Blood diseases such as leukemia and lymphoma are currently treated with bone marrow transplants—a transfer of blood stem cells from a healthy person to a patient in need. But the demand for patient-matched blood stem cells far exceeds their availability, and many patients go without. To bypass the need for donations, University of California San Diego School of Medicine researchers are using zebrafish and human cells to determine how to grow blood stem cells in a laboratory dish. […]

Rice University synthetic biologists have hacked bacterial sensing with a plug-and-play system that could be used to mix-and-match tens of thousands of sensory inputs and genetic outputs. The technology has wide-ranging implications for medical diagnostics, the study of deadly pathogens, environmental monitoring and more. […]

Researchers have been using "Fluorescence in situ hybridization" (FISH) analysis for decades to literally fish for specific DNA and RNA sequences in intact cells and tissues within their vast seas of nucleic acid molecules. Because of its ability to light specific sequences up under the microscope at the exact locations at which they reside, FISH has come to be a go-to method in the diagnosis of chromosomal abnormalities, investigation of the 3-D organization of genomes in cells' nuclei, […]

Historic climate change events can have a lasting impact on the genetic diversity of a species, reveals a new study published in Current Biology. This unexpected finding emerged from an analysis of the alpine marmot's genome. […]